An Epigenetic Approach for Finding Tumor Suppressors
نویسندگان
چکیده
منابع مشابه
Epigenetic silencing of novel tumor suppressors in malignant melanoma.
Malignant melanoma is a common and frequently lethal disease. Current therapeutic interventions have little effect on survival, emphasizing the need for a better understanding of the genetic, epigenetic, and phenotypic changes in melanoma formation and progression. We identified 17 genes that were not previously known to be silenced by methylation in melanoma using a microarray-based screen fol...
متن کاملA New Approach for Finding an Optimal Solution for Grey Transportation Problem
In ordinary transportation problems, it is always supposed that the mileage from every source to every destination is a definite number. But in special conditions, such as transporting emergency materials when natural calamity occurs or transporting military supplies during wartime, carrying network may be destroyed, mileage from some sources to some destinations are no longer definite. It is u...
متن کاملTumor suppressors: enhancers or suppressors of regeneration?
Tumor suppressors are so named because cancers occur in their absence, but these genes also have important functions in development, metabolism and tissue homeostasis. Here, we discuss known and potential functions of tumor suppressor genes during tissue regeneration, focusing on the evolutionarily conserved tumor suppressors pRb1, p53, Pten and Hippo. We propose that their activity is essentia...
متن کاملOncogenes and Tumor Suppressors
Our understanding of estrogen (17b-estradiol, E2) receptor biology has evolved in recent years with the discovery and characterization of a 7-transmembrane-spanning G protein–coupled estrogen receptor (GPER/GPR30) and the development of GPER-selective functional chemical probes. GPER is highly expressed in certain breast, endometrial, and ovarian cancers, establishing the importance of noninvas...
متن کاملNetworks of tumor suppressors
The concept of tumor suppressor networks comes as a logical consequence of the increasing understanding of the biology of tumor suppressor genes and oncogenes. Indeed, it has been gratifying to realize during the past decade that the products of tumor suppressor genes and oncogenes are often involved in the kind of guardian–delinquent relationship, or cat-and-mouse game suggested by the genetic...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Cycle
سال: 2003
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.2.1.251